<?xml version="1.0" encoding="utf-8"?><rss version="2.0"><channel><title>Latest technologies from King's Business</title><link>http://kingsbusiness.technologypublisher.com</link><description>Be the first to know about the latest inventions and technologies available from King's College London</description><language>en-US</language><pubDate>Tue, 07 Apr 2026 11:40:11 GMT</pubDate><lastBuildDate>Mon, 18 Jul 2022 06:56:58 GMT</lastBuildDate><docs>http://blogs.law.harvard.edu/tech/rss</docs><webMaster>kingsbusiness-info@kcl.ac.uk</webMaster><copyright>Copyright 2026, King's Business</copyright><item><title>Time-Triggered Federated Learning over Wireless Networks</title><caseId>501/2980</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47707</link><description><![CDATA[&shy;Summary:&nbsp;A Federated Learning Algorithm that Optimizes the Communication Overhead among Multiple Users

What

Federated learning is a form of collaborative machine learning, which allows to maintain user&rsquo;s privacy while using user&rsquo;s data. The proposed technology is a time-triggered algorithm for exchanging and aggregating data between local users and a global server in federated learning. The method allows to improve convergence time and accuracy in federated learning, if compared to traditional models. 

Why

The emerging federated learning framework offers a new way to ...]]></description><pubDate>Mon, 18 Jul 2022 06:56:58 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47707</guid></item><item><title>MIDI – MRI Deep Learning Identification of Brain Abnormalities</title><caseId>501/2927</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47706</link><description><![CDATA[&shy;Summary:&nbsp;A clinically validated tool to identify abnormalities on brain images obtained via magnetic resonance. &nbsp;

What

An automated tool for detecting abnormalities in brain medical images. The technology, called also the MIDI project, allows to improve medical triaging and can represent a valid help for clearing reporting backlogs. 

Why

The growing demand for head magnetic resonance imaging (MRI) examinations, along with a global shortage of radiologists, has led to an increase in the time taken to report head MRI scans in recent years.

In the UK alone, approximately 330,0...]]></description><pubDate>Mon, 18 Jul 2022 06:56:24 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47706</guid></item><item><title>Scribble: Optimised Segmentation of Medical Images through AI</title><caseId>501/2807</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47705</link><description><![CDATA[&shy;Summary:&nbsp;A semi-automated, artificial-intelligence based, interactive method for selecting a structure in a medical image, that requires only limited input from the users. 

&nbsp;

&nbsp;

What

&nbsp;

Segmentation is used extensively in medical imaging to highlight specific structures (e.g. an organ, a blood vessel or a tumour) and locations that should be analysed more closely.&nbsp; Researchers at King&rsquo;s have developed a segmentation technique termed &ldquo;Scribble&rdquo;, which uses machine learning to create a first segmentation of a medical image. Users interact by dra...]]></description><pubDate>Mon, 18 Jul 2022 06:54:57 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47705</guid></item><item><title>Kit for PET Imaging Agent to Support Regenerative Medicine Development</title><caseId>501/2786</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47704</link><description><![CDATA[&shy;Summary:&nbsp;Monitoring the fate of cells given to patients during regenerative medicine and cell therapies is an important milestone in their approval process.&nbsp; Development of a simplified, one-step kit for &nbsp;positron emission tomography imaging using 89Zr-oxine by researchers atKing&rsquo;s makes such tracking easier.&nbsp;

&nbsp;

What

&nbsp;

A kit for in-hospital preparation of radiopharmaceutical compounds containing the imaging agent zirconium-89-oxine ([89Zr]Zr-oxine) for positron emission tomography&nbsp; starting from commercially supplied [89Zr]Zr-oxalate.&nbsp; The...]]></description><pubDate>Mon, 18 Jul 2022 06:53:57 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47704</guid></item><item><title>Solid NURBS Parametrisation for Iso-geometric Analysis</title><caseId>501/2769</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47703</link><description><![CDATA[&shy;Summary: A resolution-free parametrisation of complex 3D structures using Non-Uniform Rational B-Splines (NURBS) to enable next-generation of simulations with iso-geometric analysis.

&nbsp;

What

&nbsp;

A method to compactly parametrise 3D solid structures for next-generation finite-element analysis from different input data. The method uses a minimal plurality of 3D Non-Uniform Rational B-Splines (NURBS) solid elements and determines a conforming parametric scaffolding specifically formulated for modelling bifurcations, such as vascular networks.

&nbsp;

Why

&nbsp;

Numerical simula...]]></description><pubDate>Mon, 18 Jul 2022 06:53:13 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47703</guid></item><item><title>Biological Flow Simulations Using Graphs</title><caseId>501/2768</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47702</link><description><![CDATA[&shy;Summary:&nbsp;A method for automate high-performance flow characteristics simulations using graph structures. This allows to quantify complex behaviour in large-scale biological networks.

&nbsp;

What

&nbsp;

A method to compute flow characteristics from 3D images of biological networks, such as the patient vasculature or airways. The geometrical features are automatically projected on a graph structure. Flow-dynamic equations are then solved using an electrical-analogue method for different configurations. This allows to account for physio-pathological behaviours of large and complex l...]]></description><pubDate>Mon, 18 Jul 2022 06:52:40 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47702</guid></item><item><title>[18F]FDOPA PET imaging – a Biomarker for Treatment Stratification in Psychosis</title><caseId>501/2750</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47701</link><description><![CDATA[&shy;Summary:&nbsp;An automated method, based on [18F]FDOPA PET imaging and artificial intelligence, to predict the treatment response of psychotic patients to first-line antipsychotics. 

&nbsp;

What

&nbsp;

A short imaging protocol and a machine learning algorithm designed to distinguish patients with schizophrenia who are unlikely to respond to first-line antipsychotic drugs from those who will respond at first episode. &nbsp;&nbsp;

&nbsp;

Why

&nbsp;

Schizophrenia and related psychotic disorders are amongst the leading causes of global disability. Antipsychotic drugs are central to tr...]]></description><pubDate>Mon, 18 Jul 2022 06:51:48 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47701</guid></item><item><title>18F-Radiotracer for Oxidative Stress PET Imaging</title><caseId>501/2657</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47700</link><description><![CDATA[&shy;Summary:&nbsp;An 18F-radiotracer able to detect oxidative stress via positron emission tomography (PET).

&nbsp;

What

A radiotracer based on 18F-labelled molecular probe that allows imaging of Reactive Oxygen Species (ROS) stress. It can be used for the early diagnosis of cardiovascular, neurodegenerative diseases, and cancers and inflammatory conditions.

&nbsp;

Why

Oxidative stress underlies the pathology of many human diseases, including neurodegenerative diseases (e.g., Parkinson&rsquo;s and Alzheimer&rsquo;s) as well as cardiovascular conditions (e.g., cardiac hypertrophy, athero...]]></description><pubDate>Mon, 18 Jul 2022 06:50:50 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47700</guid></item><item><title>Nektar1D: A Numerical Code for Solving 1-D Equations of Blood Flow</title><caseId>501/2648</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47699</link><description><![CDATA[&shy;Summary:&nbsp;A code for computing blood flow and blood pressure drop in a given network of compliant vessel.

&nbsp;

What

&nbsp;

Nektar1D is a code for solving nonlinear, one-dimensional (1-D) equations of&nbsp;blood flow in any given network of compliant vessels, subject to boundary and initial conditions.

&nbsp;

Why

&nbsp;

Understanding how the shapes of pressure and flow waves relate to the physical properties of the cardiovascular system is clinically relevant for studying and predicting cardiovascular diseases. Several numerical models have been introduced in the last decades...]]></description><pubDate>Mon, 18 Jul 2022 06:50:12 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47699</guid></item><item><title>Diagnosis of Coronary Artery Disease through Medical Imaging</title><caseId>501/2332</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47698</link><description><![CDATA[&shy;What

&nbsp;

A set of tools for assessing the presence of coronary artery disease using non-invasive and automatic techniques for processing medical images.

&nbsp;

Why

&nbsp;

Myocardial ischemia, or coronary artery disease is the most common of the cardiovascular diseases and is one of the leading causes of death worldwide.

Up today, the standard diagnostic tools for myocardial ischemia are represented by invasive techniques, such as coronary catheterization, i.e. the insertion of a catheter in the coronary arteries. However, up to 40% of patients referred for coronary catheterizati...]]></description><pubDate>Mon, 18 Jul 2022 06:48:50 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47698</guid></item><item><title>Pressure Drop Estimation from Blood Flow Profiles</title><caseId>501/2245</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47697</link><description><![CDATA[Summary

A method for accurate, efficient and non-invasive assessment of the pressure drop in the cardiovascular system&nbsp;using time-varying blood velocity profiles from from any flow imaging techniques.&nbsp;This technology will improve the screening power of current clinical practice&nbsp;and will reduce the need for catheterisation procedures.

What

A technology that allows an accurate estimate of pressure drops within the cardiovascular system from blood flow imaging, also in the presence of blood flow constrictions. The technology has been designed to work with any imaging techniques ...]]></description><pubDate>Mon, 18 Jul 2022 06:46:23 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47697</guid></item><item><title>Pressure Drop Estimation from 3D Blood Flow Profiles</title><caseId>501/2788</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47696</link><description><![CDATA[Summary

A method&nbsp; for accurate and non-invasive assessment of the pressure drop in blood flow using time-varying 3D blood velocity data acquired via phase contrast MRI.

What

A technology for estimating pressure drops within the cardiovascular system from 3D blood flow imaging. The estimate can predict pressure differences also in the presence of turbulent blood flow. The technology can be used for improving risk stratification and clinical decision-making in several conditions, including vessel stenosis and hearth conditions, such as valve stenosis or hypertrophic cardiomyopathy.

Why
...]]></description><pubDate>Mon, 18 Jul 2022 06:22:09 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47696</guid></item><item><title>Patient-Specific Brain Networks from BOLD-fMRI</title><caseId>501/2743</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47695</link><description><![CDATA[&shy;Summary:&nbsp;A method for analysing functional magnetic resonance (fMRI) images to identify brain networks in task and resting-state experiments.

&nbsp;

What

&nbsp;

Blood-oxygen-level dependent functional MRI (BOLD-fMRI) measures change in neuronal activity by detecting alterations in brain blood oxygenation. High oxygenation levels are associated with increased blood perfusion, and ultimately increased neuronal activation. The proposed technology allows to process time-varying BOLD-fMRI scans to obtain patients-specific brain networks and their corresponding neural activation profil...]]></description><pubDate>Mon, 18 Jul 2022 06:21:54 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47695</guid></item><item><title>Data Transmission via Multimode Fibres for Medical Imaging and Telecommunication</title><caseId>501/2811</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47694</link><description><![CDATA[Summary:&nbsp;a cost-effective and reliable data transmission method based on a time-efficient characterisation of multimode fibers, which can be used in several applications, including medical imaging and telecommunication systems. 

What

Multimode fibers (MMFs) are large core optical fibers that are commonly used to transmit information with light in telecommunications. Researchers at King&rsquo;s developed a novel data transmission method based on MMFs, after discovering that under specific conditions the input and output intensity distributions of MMFs have a pseudo-linear behaviour. This...]]></description><pubDate>Mon, 18 Jul 2022 06:21:36 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47694</guid></item><item><title>Phantom for Calibrating Cardiac Magnetic Resonance</title><caseId>501/1825</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47693</link><description><![CDATA[What

&nbsp;

A perfusion phantom that simulates myocardial first-pass perfusion, allowing comparisons between different magnetic resonance techniques and validation of the results against a true gold standard.

&nbsp;

Why

&nbsp;

Myocardial ischemia, or coronary artery disease is one of the leading causes of death worldwide.

Quantitative cardiac magnetic resonance (CMR) perfusion imaging is steadily being introduced into clinical routine for the assessment of coronary artery disease. Conventional CMR perfusion acquisition requires the injection of a bolus of contrast agent in the patient t...]]></description><pubDate>Mon, 18 Jul 2022 06:21:07 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47693</guid></item><item><title>Machine Learning for Guiding the Treatment of Arrythmias</title><caseId>501/2916</caseId><link>http://kingsbusiness.technologypublisher.com/technology/47692</link><description><![CDATA[Summary:&nbsp;A catheter and a machine-learning based method for identifying&nbsp;portions of the cardiac tissue that sustain arrhythmias during clinical procedures . The identified portions represent possible targets for ablation therapy to correct arrhythmias.

What

A catheter and a machine-learning algorithm for identifying pathological tissues that tethers arrhythmias, and specifically Atrial Fibrillation (AF). The proposed technology integrates data set of numerical simulations of cardiac arrhythmias computed on a cohort of personalised computer models&nbsp;with machine learning classifi...]]></description><pubDate>Mon, 18 Jul 2022 06:20:50 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/47692</guid></item><item><title>ReDent - Inhibitor of GSK3 activity to stimulate dentine repair</title><caseId>501/2308</caseId><link>http://kingsbusiness.technologypublisher.com/technology/46596</link><description><![CDATA[&shy;Background


Dental caries remains a major clinical problem and although current treatments are effective, they are &ldquo;temporary repairs&rdquo; rather than complete structural and functional regeneration of dentine.&nbsp; Despite many years of research and development into dental materials, the basic principles on which tooth restorations are based have changed little and still involve the use of inorganic filling materials to repair cavities.

Dentine is a living tissue and a source of important biological factors. If tooth cavities could be treated by stimuli that promote the format...]]></description><pubDate>Mon, 09 May 2022 01:08:22 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/46596</guid></item><item><title>A method for reconstructing the 3D surface of tubular organs from endoscope shape and camera data</title><caseId>501/2860</caseId><link>http://kingsbusiness.technologypublisher.com/technology/46018</link><description>The Problem 

In colonoscopy, a camera is inserted through the colon, a long tubular organ, in order to screen the internal tissue for cancer and other medical problems. However, inspection quality varies greatly with, even under optimal conditions, on average only 81% of the colon being inspected. A key cause for this is acute bends in the colon which can create blindspots. This is because the outsides of these bends are readily visible to the camera, but the colonoscope must be deliberately reinserted and hooked around the bend to view the insides.

The Solution

We present a method for dete...</description><pubDate>Fri, 04 Mar 2022 07:16:55 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/46018</guid></item><item><title>Ad-Hoc Communication System for Intelligent Transportation with Simultaneous Transmission and Sensing</title><caseId>501/2910</caseId><link>http://kingsbusiness.technologypublisher.com/technology/45305</link><description>Background


	The performance of an intelligent transportation system depends on many factors, but most significantly the supporting V2X communication technologies.
	3GPP standardised C-V2X technology is shown only being able to support basic applications, and advanced applications require a better communication system.
	An ad-hoc V2X scenario is regarded as the baseline mode since safety also has to be guaranteed when vehicles are outside the coverage of base stations, or when the connection to a base station is not stable.


Challenges


	A conventional acknowledgement mechanism cannot be de...</description><pubDate>Mon, 08 Nov 2021 07:01:26 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/45305</guid></item><item><title>Soft growing steerable robots for intraluminal navigation</title><caseId>501/2896</caseId><link>http://kingsbusiness.technologypublisher.com/technology/45251</link><description><![CDATA[Background: 

	As catheters are inserted intraluminally, they exercise shear forces on the anatomy walls. These forces can cause damage to sensitive lumens such as vessels, mammary ducts, renal channels, or bile ducts.
	Current robotic catheters do not deviate from this conventional actuation paradigm, and therefore face the same problems.



The Problem 


	Engineering solutions are required to achieve better steering of robotic catheters in addition to minimising the forces exerted on the anatomy.
	Growing, also called everting, robots elongate from their tip, through the &ldquo;unfolding&rd...]]></description><pubDate>Thu, 04 Nov 2021 08:55:07 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/45251</guid></item><item><title>Constant Saturation of Magnetization Transfer in clinical MR relaxometry</title><caseId>501/2473</caseId><link>http://kingsbusiness.technologypublisher.com/technology/45215</link><description><![CDATA[
Background: 


	The contrast on an MRI image is affected by many factors, but most significantly the tissue &lsquo;relaxation&rsquo; times.
	Standard radiology practice is to make MR images with different contrasts to be interpreted by a radiologist.
	Modern quantitative MRI seeks instead to measure relaxation times to enable precision diagnosis reconstruction.



The Problem 


	Although relaxation times are important, they are not a complete description of the MRI signal in human tissue
	So-called &lsquo;magnetization transfer&rsquo; (MT) occurring between protons in water (which we view wi...]]></description><pubDate>Mon, 01 Nov 2021 06:56:44 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/45215</guid></item><item><title>Active guide wire and device decoupling with parallel transmit MRI</title><caseId>501/2249</caseId><link>http://kingsbusiness.technologypublisher.com/technology/45214</link><description><![CDATA[
Background: 


	Image guided intravascular interventions are used to diagnose/treat a wide range of conditions. For cardiac applications they require devices to be inserted via a major vessel (e.g. in the groin) that are then steered through the patient&rsquo;s vasculature to the heart. This may require guidewires and plastic/metal mesh catheters to contain or guide the device. These procedures typically occur under high frame rate x-ray imaging to allow the interventionist to visualise the devices and guide them to the required location in the anatomy.



The Problem 


	High frame rate x-ra...]]></description><pubDate>Mon, 01 Nov 2021 06:54:25 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/45214</guid></item><item><title>Virtual Reality in MRI</title><caseId>501/2646</caseId><link>http://kingsbusiness.technologypublisher.com/technology/45145</link><description><![CDATA[&nbsp;

Improving the experience of MR Imaging subjects

&nbsp;

Briefly the innovation is a patient-controlled VR system to allow the scanning subject to control by eye movements a virtual environment.&nbsp; There are items displayed in the virtual world which correspond to the sounds made by an MRI scanner during its operation and the feeling of the patient table going into the bore of the MR scanner.

&nbsp;

The King&#39;s lead researcher, Prof Joseph Hajnal,&nbsp;works extensively on paediatric imaging but the system would also be useful in support of MRI scanning of claustrophobic or con...]]></description><pubDate>Tue, 19 Oct 2021 09:26:37 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/45145</guid></item><item><title>Novel image reconstruction technology</title><caseId>501/2538</caseId><link>http://kingsbusiness.technologypublisher.com/technology/44931</link><description><![CDATA[Background

Image reconstruction arises in many fields such as medical and pre-clinical imaging (e.g. positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI) and computed tomography (CT)). Image reconstruction is critically important: it takes the raw data from a scanner and represents it as a meaningful image to the user. However, an ongoing major challenge is the presence of noise in the raw data (especially in PET or SPECT), meaning that many possible images can represent the raw data.


Academics at King&rsquo;s College Londo...]]></description><pubDate>Mon, 20 Sep 2021 08:28:41 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/44931</guid></item><item><title>A new Manufacturing Process for Solid-State Li Metal Batteries (SSLMBs)</title><caseId>501/2873</caseId><link>http://kingsbusiness.technologypublisher.com/technology/44930</link><description><![CDATA[Rechargeable batteries that provide increased specific energy and improved safety over commercial Lithium ion batteries (LIBs) are in demand for applications such as electric vehicles (EVs), all-electric aircraft and the grid-scale storage of electricity from renewable but intermittent electrical generation.

Inventors at King&rsquo;s College London and Oxford University have come up with novel type of rechargeable solid-state battery (SSB) technology that addresses the two key limitations in this field namely safety and higher specific energy.

Solid-state Li metal batteries (SSLMBs) combine ...]]></description><pubDate>Mon, 20 Sep 2021 02:35:38 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/44930</guid></item><item><title>Primary care, non-invasive detection of gastric reflux</title><caseId>501/2547</caseId><link>http://kingsbusiness.technologypublisher.com/technology/44009</link><description>Summary
Gastro-oesophageal reflux disease (GORD/GERD), where stomach acid enters the oesophagus, affects 10-20% of the population. There is currently no method available to test for GORD in a primary care setting. Of particular difficulty is testing for extra-oesophageal reflux where acid reflux travels into the airway space and can cause airway problems such as exacerbated asthma and chronic cough. A blanket approach of prescribing anti-reflux medication, with many unwanted side-effects, is often performed in the absence of an accurate diagnosis. Our simple device has potential to alter the t...</description><pubDate>Tue, 15 Jun 2021 01:04:06 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/44009</guid></item><item><title>Stratification biomarker for anti-PCSK9 therapy</title><caseId>501/2789</caseId><link>http://kingsbusiness.technologypublisher.com/technology/42112</link><description><![CDATA[
Summary: An assay to identify &lsquo;responders vs non-responders&rsquo; to anti-PCSK9 therapy. 


Technology Overview


Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates circulating low-density lipoprotein cholesterol (LDL-C) through the hepatic LDL receptor degradation pathway. It is a known therapeutic target to further lower LDL-C in patients suffering from dyslipidemia/hypercholesterolemia and who are already on maximal statin therapy. Currently there are several anti-PCSK9 therapies either in development or on the market. However, potent LDL lowe...]]></description><pubDate>Mon, 19 Oct 2020 08:19:45 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/42112</guid></item><item><title><![CDATA[Novel localisation microscopy technique for high density & artefact free images]]></title><caseId>501/2523</caseId><link>http://kingsbusiness.technologypublisher.com/technology/27606</link><description><![CDATA[
&nbsp;

Super-resolution and localization fluorescence microscopy techniques have attracted considerable attention in the past decade in particular including the Nobel Prize in Chemistry, 2014.

&nbsp;

Academics at King&rsquo;s College London have developed a novel method based on multiscale temporal filtering to enable high density, artefact free and multi colour localisation microscopy.

&nbsp;

Localisation microscopy is a type of super-resolution microscopy that allows images to be taken with resolution better than the diffraction limit.&nbsp; While a popular technique, localisation micr...]]></description><pubDate>Wed, 25 Apr 2018 04:19:45 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/27606</guid></item><item><title>Sensing Structure based on Electron Tunnelling in Plasmonic Metamaterial</title><caseId>501/2361</caseId><link>http://kingsbusiness.technologypublisher.com/technology/27473</link><description><![CDATA[
What

An adaptable, ultra-sensitive, inexpensive sensing structure based on a novel electrically driven plasmonic metamaterial, based on the electron tunnelling effect.

&nbsp;

Why

There is a rising demand for gas sensors, such as oxygen gas sensors used in the medical sector, for anaesthesia machines, ventilators, and the like.

Similarly, hydrogen sensors market is likely to grow significantly over the coming years, in view of the potential role of green hydrogen for more sustainable energy systems. 

Furthermore, there is a need to monitor chemical reactions, where precise stimulation an...]]></description><pubDate>Wed, 04 Apr 2018 05:47:25 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/27473</guid></item><item><title>Assay for predicting conversion to Alzheimer's Disease and Monitoring disease progression</title><caseId>501/2330</caseId><link>http://kingsbusiness.technologypublisher.com/technology/24962</link><description><![CDATA[An in vitro assay of human hippocampal neurogenesis (HN) which utilises an established human hippocampal progenitor cell line and patients&rsquo; human serum to provide prediction of progression from mild cognitive impairment (MCI) to Alzheimer&rsquo;s Disease (AD) and helps distinguish those individuals diagnosed with MCI who will or will not develop AD.&nbsp;Technology OverviewDementia due to AD is preceded by a long preclinical stage, followed by diagnosis of MCI and not everyone diagnosed with MCI will develop AD. It is generally agreed that any putative disease-modifying therapies would b...]]></description><pubDate>Fri, 24 Mar 2017 03:07:13 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/24962</guid></item><item><title>Novel self-propelled soft worm like endoscopic robot</title><caseId>501/2395</caseId><link>http://kingsbusiness.technologypublisher.com/technology/24572</link><description><![CDATA[Introduction:&nbsp;Academics at King&rsquo;s College London have developed a novel worm-inspired, multi-segment robotic endoscope with multiple degrees of freedom segments. The novelty of this design is that the robot is able to drive forwards and backwards, anchor itself, steer while inside a tubular structure and control the orientation of an end-mounted camera all by bending its flexible segments.&nbsp;Colorectal cancer accounts for approximately 10% of all known cancer cases worldwide and is therefore a serious cost to health services. There is evidence to suggest that fear of discomfort i...]]></description><pubDate>Mon, 13 Mar 2017 04:42:24 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/24572</guid></item><item><title>MR Elastography (MRE) for non-invasive diagnosis, staging and monitoring of tissue pathologies</title><caseId>501/2110</caseId><link>http://kingsbusiness.technologypublisher.com/technology/24100</link><description><![CDATA[
&nbsp;

What

&nbsp;

The detection of pathological tissue alterations by manual palpation is a simple but essential diagnostic tool used by clinicians.&nbsp; The &quot;virtual palpation&quot; of tissue has now become feasible using Magnetic Resonance Elastography (MRE).&nbsp; Researchers at King&rsquo;s College London have developed novel MRE units that work alongside standard MRI scanners to provide high quality information on tissue characteristics following application of controlled vibrational stresses to a patient.&nbsp; With many disease states impacting upon biomechanics, the potentia...]]></description><pubDate>Fri, 17 Feb 2017 03:50:08 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/24100</guid></item><item><title>Optical Switch</title><caseId>MP-15/0002</caseId><link>http://kingsbusiness.technologypublisher.com/technology/19275</link><description><![CDATA[Summary One of the current aims of nanotechnology is the replacement of &lsquo;slow&rsquo; electronic devices with &lsquo;fast&rsquo; photonic (light based) ones. Vertical-Cavity Surface-Emitting Lasers (VCSELs) are a promising technology for optical devices as they are compact, inexpensive and power efficient. VCSELs have the second highest production volume of all semiconductor lasers owing to the large number of commercial applications such as Photonic Integrated Circuits (PICs), data transmission, printing and computer mice. In this context, Researchers from King's College London have inve...]]></description><pubDate>Fri, 08 May 2015 03:44:24 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/19275</guid></item><item><title>Optical Hydrogen Sensor based on Metamaterial</title><caseId>501/1889</caseId><link>http://kingsbusiness.technologypublisher.com/technology/17932</link><description><![CDATA[
What

&nbsp;

Researchers at King&rsquo;s College London have developed an inexpensive, ultrasensitive, and all-optical hydrogen sensor based on a novel plasmonic metamaterial.

&nbsp;

Why

&nbsp;

Hydrogen can be used in a wide array of industrial applications: for example, in the petrochemical and chemical industries, but also as fuel in vehicular transportation. It is expected that green hydrogen will be a major player in the next clean energy revolution.&nbsp;

However, with the increased use of hydrogen comes increased danger: fires and protentional detonation can occur at concentration...]]></description><pubDate>Thu, 15 Jan 2015 02:34:04 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/17932</guid></item><item><title>Counterfeit Drug Detection</title><caseId>MP-14/0007</caseId><link>http://kingsbusiness.technologypublisher.com/technology/17468</link><description><![CDATA[Non-invasive, non-destructive authentication of packaged medicines&nbsp;Safe Medicines, Good Health: In 2013, the United Nations Human Rights Council (UNHCR) adopted a resolution (A/HRC/RES12/24) on access to medicines that stressed &ldquo;the responsibility of States to ensure access to all, without discrimination, of medicines, in particular essential medicines, that are affordable, safe, effective and of good quality&rdquo;.&nbsp; Current methods for authenticating medicines rely on optical spectroscopy or wet chemistry and for best effect require that the pill be removed from the packaging...]]></description><pubDate>Wed, 05 Nov 2014 07:33:38 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/17468</guid></item><item><title>Non-Ionising Imaging</title><caseId>501/1834</caseId><link>http://kingsbusiness.technologypublisher.com/technology/15666</link><description><![CDATA[Technology Overview&nbsp;The technology uses light at a given near infrared wavelength [NIR] to create a transmission image of dental caries (decay). Healthy hard tissues (enamel, dentine and cementum) tend to &lsquo;guide&rsquo; light of this wavelength, leading to a bright image, whereas decay and other inhomogeneities cause optical scattering. This produces high definition images of dental caries. This is very well illustrated in the lower image below, where the caries is obviously visible. The device is designed to utilize commercial-off-the-shelf technology for production at commercial sc...]]></description><pubDate>Tue, 05 Aug 2014 06:29:47 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/15666</guid></item><item><title>Saliva Guard  (Xerostomia Device)</title><caseId>501/0876</caseId><link>http://kingsbusiness.technologypublisher.com/technology/15665</link><description><![CDATA[ProblemDebilitating oral dryness (Xeorstomia) is a common, poorly treated component of orofacial cancer radio/chemotherapy and of Sjogren&rsquo;s disease (an age-related onset auto-immune condition).&nbsp; A device is needed&nbsp;to enhance patient quality of life by reducing pain, ameliorating swallowing difficulty and rampant decay while improving speech and sleep quality by effective oral delivery&nbsp;of&nbsp;artificial saliva and associated therapeutics.&nbsp;SolutionThe research team have developed a simple device, similar to an irrigated gum-shield,&nbsp;to prevent the mouth&nbsp;from d...]]></description><pubDate>Tue, 05 Aug 2014 06:23:11 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/15665</guid></item><item><title>Candidalysin: Anti-fungal target and immunotherapeutic candidate</title><caseId>501/1863</caseId><link>http://kingsbusiness.technologypublisher.com/technology/15466</link><description><![CDATA[
The Problem 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 

Candida albicans is an opportunistic fungal pathogen, which normally exists as a commensal of the oral cavity and gastrointestinal tracts and frequently causes superficial vaginitis infections. Moreover, common clinical procedures, such as gastrointestinal surgery, implantation of a central venous catheter or antibiotic treatment are major risk factors for life-threatening systemic candidiasis.&nbsp; Systemic candidiasis is now the third most common cause of...]]></description><pubDate>Fri, 04 Jul 2014 06:03:32 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/15466</guid></item><item><title>Immersive Sound</title><caseId>MP-13/0002</caseId><link>http://kingsbusiness.technologypublisher.com/technology/11981</link><description><![CDATA[&ldquo;I would like to congratulate you on the apparent naturalness, at least from a first hearing on modest loudspeakers. The source movement was easily detectable and fairly easy to locate.&rdquo;Francis RumseyChair, Technical Council at Audio Engineering Society&nbsp;&ldquo;It was great to see how the project has evolved and I'm really impressed by the result. By way of comparison we checked out an ambisonic system later in the day. Having had your demo in the morning the lack of location precision in the ambisonic&nbsp; system was very apparent.&rdquo;James Hall, Jawbone Inc.&nbsp;Imagine ...]]></description><pubDate>Tue, 05 Mar 2013 04:23:35 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/11981</guid></item><item><title>HIV-1 integrase (IN) monoclonal antibody - Clone IN-2</title><caseId>001/0013</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4955</link><description><![CDATA[Reagent nameHIV-1 integrase (IN) monoclonal antibody (#IN-2)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 integrase protein (clade B, HXB-3 isolate)&nbsp;RelevanceHIV-1 expresses the integrase (IN) protein as part of the polymerase gene.&nbsp; It is the viral enzyme that catalyses the insertion of viral DNA into the chromosomal DNA of an infected cells.&nbsp; Integrase is essential for viral growth and is a therapeutic target.&nbsp;Cross-reactivityNo cross-reactivity with no...]]></description><pubDate>Wed, 14 Apr 2010 08:46:35 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4955</guid></item><item><title>Mouse anti-human actin antibody - Clone MM2/193</title><caseId>501/0297</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4954</link><description><![CDATA[Reagent NameMouse anti-human actin antibody&nbsp;ImmunogenHuman platelet membranes.&nbsp;RelevanceActin is a major protein found in most cells and is important in cell motility and contraction. It is a major component of the cytoskeleton. &nbsp;Cross reactivityRecognises human actin as a 42-47 kDa protein in platelet lysates.&nbsp;SpecificityEpitope is not mapped.&nbsp;Tested ApplicationsWestern blotting.&nbsp;Raised inMouse&nbsp;ClonalityMonoclonal]]></description><pubDate>Wed, 14 Apr 2010 08:46:32 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4954</guid></item><item><title>Mouse anti- human filamin antibody - Clone PM6/317</title><caseId>501/0997</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4952</link><description><![CDATA[Reagent NameMouse anti- human filamin antibody&nbsp;ImmunogenHuman platelet membranes&nbsp;RelevanceFilamin (also called actin binding protein) is a structural protein that forms flexible cross-links between two actin filaments. Filamin is a homodimer of polypeptide chains each joined to the other at one end with an actin binding site. It is present in smooth muscle, fibroblasts, platelets and lymphocytes. &nbsp;Cross reactivityChicken, Guinea Pig , Human, Rat, Rabbit &nbsp;SpecificityRecognizes full length Human filamin (actin-binding protein; 270-280 kDa) as well as the 190 kDa N-terminal ca...]]></description><pubDate>Wed, 14 Apr 2010 08:46:28 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4952</guid></item><item><title>HIV-1 p24 Gag monoclonal antibody - Clone 24-4</title><caseId>501/0990</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4951</link><description><![CDATA[Reagent NameHIV-1 p24 Gag monoclonal antibody (#24-4)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 p24 Gag protein (clade B, HXB-3 isolate)&nbsp;Relevancep24 is encoded by the HIV gag gene and is an important structural component of the capsid core of the HIV particle&nbsp;Cross reactivityCross-reactivity with a ~65 kDa species in western blot&nbsp;SpecificityEpitope not yet mapped&nbsp;Tested applicationsWestern blots for clade B isolates of HIV; immunofluorescence/FACS ass...]]></description><pubDate>Wed, 14 Apr 2010 08:46:27 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4951</guid></item><item><title>HIV-1 p24 Gag monoclonal antibody - Clone 24-3</title><caseId>501/0992</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4950</link><description><![CDATA[Reagent NameHIV-1 p24 Gag monoclonal antibody (#24-3)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 p24 Gag protein (clade B, HXB-3 isolate)&nbsp;Relevancep24 is encoded by the HIV gag gene and is an important structural component of the capsid core of the HIV particle&nbsp;Cross reactivityNot tested&nbsp;SpecificityEpitope not mapped&nbsp;Tested applicationsWestern blots for clade B isolates of HIV; immunofluorescence assays.&nbsp; (not useful for immunoprecipitation assays)...]]></description><pubDate>Wed, 14 Apr 2010 08:46:26 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4950</guid></item><item><title>Mouse anti-human Integrin beta 3 (CD61) antibody - Clone PM6/13</title><caseId>501/1065</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4949</link><description><![CDATA[Reagent NameHuman Integrin beta 3 antibody&nbsp;ImmunogenHuman platelet membranes&nbsp;RelevanceIntegrin beta 3 is also known as glycoprotein IIIa and in a complex with the integrin alpha 2b subunit forms the receptor for fibrinogen, fibronectin and von Willebrand Factor on activated platelets.&nbsp; Integrin beta 3 can also complex with alpha V integrin. The antibody inhibits platelet aggregation, inhibits the binding of soluble fibrinogen to activated platelets and also inhibits adhesion of activated platelets to immobilised fibrinogen, fibronectin or vWF. &nbsp;Cross reactivityHuman and bab...]]></description><pubDate>Wed, 14 Apr 2010 08:46:25 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4949</guid></item><item><title>Mouse anti-human Vinculin antibody - Clone V284</title><caseId>501/1123</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4946</link><description><![CDATA[Reagent NameMouse anti-human Vinculin antibody&nbsp;ImmunogenPurified human platelet vinculin&nbsp;RelevanceVinculin is a 117 kDa membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton.&nbsp;Cross reactivityHuman, rabbit, rat, chicken, mouse.&nbsp;SpecificityEpitope not mapped. Recognises vinculin and a 130 kDa protein in platelets and other cells.&nbsp;Tested ApplicationsWestern blotting, immunoprecipitation, immunohistology&nbsp;Raised inMouse&nbsp;ClonalityMonoclonal&nbsp;IsotypeIgG1&nbsp;ReferencesPorter ...]]></description><pubDate>Wed, 14 Apr 2010 08:46:19 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4946</guid></item><item><title>Mouse anti-human integrin alpha 2b (CD41) antibody - Clone PM6/248</title><caseId>501/1022</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4943</link><description><![CDATA[Reagent NameMouse anti-human integrin alpha 2b (CD41) antibody&nbsp;ImmunogenHuman platelet membranes&nbsp;RelevanceIntegrin alpha 2b is also known as glycoprotein IIb and in a complex with the integrin beta 3 subunit forms the receptor for fibrinogen, fibronectin and von Willebrand Factor on activated platelets. The antibody activates platelets under stirring conditions and inhibits at higher doses . The antibody inhibits binding of fibrinogen, fibronectin and vWF in static adhesion assays and inhibits binding of soluble fibrinogen and fibronectin to ADP activated platelets.&nbsp;Cross reacti...]]></description><pubDate>Wed, 14 Apr 2010 08:46:11 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4943</guid></item><item><title>Human Thyrotrophin Receptor Monoclonal Antibody - Clone 2C11[MASTER RECORD FOR MONITORING INCOME TO / FROM SGUL ON SHEPHERD mAbs]</title><caseId>501/0575</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4942</link><description><![CDATA[The human thyrotrophin receptor (TSHR) is found primarily in epithelial cells of thyroid follicles where it induces (by cAMP) the phospholipase C and protein kinase A signal transduction pathways.&nbsp; TSHR is the major pathogenic autoantigen in human autoimmune thyroid Graves&rsquo; disease.&nbsp;&nbsp;LanesTSHRGlycosylated&nbsp; TSHRTSHR - GSTResidues 125-369 TSHR - GST&nbsp;Product TypeHybridoma for monoclonal antibodyImmunogenBacterially expressed extracellular domain (residues 1-415 of human TSHR fused to GST)Cross ReactivityCross-reacts with human and theoretically with rat, pig, sheep,...]]></description><pubDate>Wed, 14 Apr 2010 08:46:10 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4942</guid></item><item><title>HIV-1 p17 Gag monoclonal antibody - Clone 17-1</title><caseId>501/0987</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4939</link><description><![CDATA[Reagent NameHIV-1 p17 Gag monoclonal antibody (#17-1)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1.&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 p17 Gag protein (clade B, HXB-3 isolate)&nbsp;Relevancep17 is encoded by the HIV gag gene and is an important structural component of the HIV particle&nbsp;Cross reactivityNot tested&nbsp;SpecificityEpitope not mapped&nbsp;Tested applicationsWestern blots for clade B isolates of HIV; immunoprecipitation assays; immunofluorescence/FACS assays&nbsp;Raised in Mouse&nbsp;Clonality...]]></description><pubDate>Wed, 14 Apr 2010 08:46:02 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4939</guid></item><item><title>Mouse Anti-T Cell / Neutrophil Marker Antibody - Clone RPN3/57</title><caseId>501/1124</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4938</link><description><![CDATA[Reagent NameMouse Anti-T Cell / Neutrophil Marker Antibody&nbsp;ImmunogenRabbit peritoneal neutrophils&nbsp;RelevanceUseful for the detection of rabbit neutrophils and T cells&nbsp;Cross reactivityNot tested&nbsp;SpecificityRecognises an antigen expressed strongly on neutrophils, thymocytes, a subset of T cells and platelets.&nbsp; Epitope not identified.&nbsp;Tested ApplicationsFlow cytometry and immunohistochemistry&nbsp;Raised inMouse&nbsp;ClonalityMonoclonal &nbsp;IsotypeIgG1&nbsp;ReferencesWilkinson JM et al. (1992) Immunol. 76: 625-30. Wilkinson JM et al. (1993) J Pathol. 170: 315-320]]></description><pubDate>Wed, 14 Apr 2010 08:46:01 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4938</guid></item><item><title>Mouse anti-human SERCA 3 antibody - Clone PL/IM430</title><caseId>501/1121</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4937</link><description><![CDATA[Reagent NameMouse anti-human SERCA 3 antibody&nbsp;ImmunogenHuman platelet intracellular membranes&nbsp;RelevanceSERCA 3 is the sarco-endoplasmic reticulum Ca2+ ATPase that sequesters Ca2+ into intracellular stores of mammalian cells. This antibody inhibits Ca2+ sequestration and Ca2+ATPase activity mediated by human SERCA3. &nbsp;Cross reactivityHuman &nbsp;SpecificityEpitope has recently been described to be between amino acids 1-236 of human SERCA3. PL/IM430 recognises a 100kDa SERCA3 protein in platelet lysates.&nbsp;Tested ApplicationsWestern blotting, immunoprecipitation, immunohistochem...]]></description><pubDate>Wed, 14 Apr 2010 08:46:00 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4937</guid></item><item><title>HIV-1 Rev monoclonal antibody - Clone Rev-4</title><caseId>501/0993</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4936</link><description><![CDATA[Reagent NameHIV-1 Rev monoclonal antibody (#Rev-4)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 Rev protein (clade B, HXB-3 isolate)&nbsp;RelevanceHIV-1 expresses the trans-activator protein Rev, which is required for virus growth as it promotes the localisation and expression of viral RNA in the cytoplasm.&nbsp; Rev is a model experimental system for studying nuclear transport.&nbsp; &nbsp;Cross-reactivityNo cross-reactivity with non-HIV-1 Rev proteins has been observed&nbs...]]></description><pubDate>Wed, 14 Apr 2010 08:45:59 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4936</guid></item><item><title>Human Complement C1q Monoclonal Antibody - Clone  IA4</title><caseId>001/0015</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4935</link><description><![CDATA[Research tool for:ImmunohistochemistryIsolation of C1q complexes&nbsp;C1q is a sub-component of the first complement component C1.&nbsp; C1q binds to IgG and IgM immune complexes, this activates C1r and C1s, which are also bound to C1q and so initiates the classical pathway of complement activation.&nbsp; C1q deficiencies are observed in agammaglobulinemia, acute glomerular nephritis, systemic lupus erythematosus, and chronic glomerular nephritis.&nbsp;Product TypeHybridoma for monoclonal antibodyImmunogenPurified human C1qCross ReactivityNo known cross reactivity with other tissue antigensSpe...]]></description><pubDate>Wed, 14 Apr 2010 08:45:54 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4935</guid></item><item><title>HIV-1 integrase (IN) monoclonal antibody - Clone IN-3</title><caseId>501/0986</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4929</link><description><![CDATA[Reagent nameHIV-1 integrase (IN) monoclonal antibody (#IN-3)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 integrase protein (clade B, HXB-3 isolate)&nbsp;RelevanceHIV-1 expresses the integrase (IN) protein as part of the polymerase gene.&nbsp; It is the viral enzyme that catalyses the insertion of viral DNA into the chromosomal DNA of an infected cells.&nbsp; Integrase is essential for viral growth and is a therapeutic target.&nbsp;Cross-reactivityNo cross-reactivity with no...]]></description><pubDate>Wed, 14 Apr 2010 08:45:43 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4929</guid></item><item><title>Human Thyrotrophin Receptor Monoclonal Antibody - Clone 3B12</title><caseId>001/0015-2</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4927</link><description><![CDATA[Research tool for:Immunoblotting Immunoprecipitation Flow cytometry Immunohistochemistry (frozen section)&nbsp;&nbsp;Product TypeHybridoma for monoclonal antibodyImmunogenBacterially expressed extracellular domain (residues 1-415) of human TSHR fused to GSTCross ReactivityCross-reacts with human and theoretically with rat, pig, sheep, mouse, dog, catSpecificityDetects residues 336-345 of human TSHRRaised in MouseIsotypeIgG1&nbsp;ReferencesShepherd PS, Da Costa CR, Cridland JC, Gilmore KS, Johnstone AP. 1999.&nbsp; Monoclonal antibodies that recognize the native human thyrotrophin receptor.&nbs...]]></description><pubDate>Wed, 14 Apr 2010 08:45:40 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4927</guid></item><item><title>HIV-1 p17 Gag monoclonal antibody - Clone 17-3</title><caseId>501/0989</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4926</link><description><![CDATA[Reagent NameHIV-1 p17 Gag monoclonal antibody (#17-3)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 p17 Gag protein (clade B, HXB-3 isolate)&nbsp;Relevancep17 is encoded by the HIV gag gene and is an important structural component of the HIV particle&nbsp;Cross reactivityNot tested&nbsp;SpecificityEpitope not mapped&nbsp;Tested applicationsWestern blots for clade B isolates of HIV; immunoprecipitation assays; immunofluorescence/FACS assays&nbsp;Raised in Mouse&nbsp;ClonalityM...]]></description><pubDate>Wed, 14 Apr 2010 08:45:40 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4926</guid></item><item><title>HIV-1 Rev monoclonal antibody - Clone Rev-6</title><caseId>501/0994</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4924</link><description><![CDATA[Reagent NameHIV-1 Rev monoclonal antibody (#Rev-6)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 Rev protein (clade B, HXB-3 isolate)&nbsp;RelevanceHIV-1 expresses the trans-activator protein Rev, which is required for virus growth as it promotes the localisation and expression of viral RNA in the cytoplasm.&nbsp; Rev is a model experimental system for studying nuclear transport.&nbsp; &nbsp;Cross-reactivityNo cross-reactivity with non-HIV-1 Rev proteins has been observed&nbs...]]></description><pubDate>Wed, 14 Apr 2010 08:45:38 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4924</guid></item><item><title>HIV-1 Vif Monoclonal Antibody - Clone 564</title><caseId>501/0996</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4923</link><description><![CDATA[Reagent NameHIV-1 Vif monoclonal antibody (#564)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 Vif protein (clade B, HXB-3 isolate)&nbsp;RelevanceHIV-1 expresses the viral infectivity factor (vif) which induces productive viral replication by inactivating the host cell anti-HIV factor APOBEC3G&nbsp;Cross-reactivityNo cross-reactivity with non-HIV-1 Vif proteins has been observed&nbsp;SpecificityEpitope not yet mapped&nbsp;Tested applicationsImmunoprecipitation assays (not use...]]></description><pubDate>Wed, 14 Apr 2010 08:45:37 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4923</guid></item><item><title>Mouse anti-human Talin antibody - Clone TA205</title><caseId>501/1122</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4921</link><description><![CDATA[Reagent NameMouse anti-human Talin antibody&nbsp;ImmunogenHuman platelet talin.&nbsp;RelevanceTalin is a cytoskeletal protein that is found concentrated in focal adhesions. It is capable of linking integrins to the actin cytoskeleton either directly or indirectly by interacting with vinculin and alpha-actinin&nbsp;Cross reactivityTA205 immunoblots a 225 kDa protein in human platelet lysates&nbsp;SpecificityEpitope resides in region 139-433 in talin.&nbsp;Tested ApplicationsImmunohistochemistry, Western blotting and immunoprecipitation.&nbsp;Raised inMouse&nbsp;ClonalityMonoclonal&nbsp;IsotypeI...]]></description><pubDate>Wed, 14 Apr 2010 08:45:33 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4921</guid></item><item><title>Mouse anti-human Glycoprotein 1b alpha (CD42b) antibody - Clone PM6/40.</title><caseId>501/1001</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4920</link><description><![CDATA[Reagent NameMouse anti-human Glycoprotein 1b alpha antibody&nbsp;ImmunogenPlatelet membranes&nbsp;RelevanceGlycoprotein 1b (GP1b) is heavily expressed in platelets and megakaryocytes. It serves as a receptor for von Willebrand Factor and thrombin.&nbsp;Cross reactivityRecognises human GP1b, other species GP1b to be tested.&nbsp;SpecificityEpitope not mapped&nbsp;Tested ApplicationsFlow cytometry, immunoflourescence, immunohistochemistry (frozen sections)&nbsp;Raised inMouse&nbsp;ClonalityMonoclonal&nbsp;IsotypeIgG1&nbsp;ReferencesThorsen LI et al 1998 Br. J. Haematol. 68, 67-74]]></description><pubDate>Wed, 14 Apr 2010 08:45:30 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4920</guid></item><item><title>Human Thyroglobulin Monoclonal Antibody - Clone 1D4</title><caseId>001/0015-1</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4919</link><description><![CDATA[Research tool forELISARadioimmunoassayIn vivo imaging&nbsp;Thyroglobulin is a large iodinated glycoprotein which is produced by the thyroid gland, functioning as a prohormone in the synthesis of thyroxine (T4) and triiodothyronine (T3).&nbsp; Levels of serum thyroglobulin are elevated in a variety of thyroid diseases, such as Grave&rsquo;s disease (goiter), subacute thyroiditis and differentiated thyroid carcinoma.&nbsp;Product TypeHybridoma for monoclonal antibodyImmunogenPurified human thyroglobulinCross ReactivityCross-reacts with baboon.&nbsp; Does not cross react with sheep, pig, bovine, ...]]></description><pubDate>Wed, 14 Apr 2010 08:45:29 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4919</guid></item><item><title>SuperBUGS: Rabbit anti-MAP1B phospho (T1265)</title><caseId>501/0561</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4918</link><description><![CDATA[Affinity purified anti-sera to the glycogen synthase kinase (GSK3b) mediated nonprimed phosphorylation site of Microtubule Associated Protein 1B (MAP1B). MAP1B is a developmentally regulated microtubule-associated phosphoprotein that regulates microtubule dynamics in growing axons and growth cones.&nbsp;King&rsquo;s DeveloperProfessor Phillip R. Gordon-WeeksReagent nameSuperBUGS: Rabbit anti-MAP1B phospho (T1265)Immunogen (peptide sequence + location; recombinant protein; native protein from which species)CSPIEKTPLGER, in which threonine was phosphorylated, were synthesised and conjugated to k...]]></description><pubDate>Wed, 14 Apr 2010 08:45:23 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4918</guid></item><item><title>Mouse anti-human Glycoprotein 1b alpha (CD42b) antibody - Clone MM2/174.</title><caseId>501/0998</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4916</link><description><![CDATA[Reagent NameMouse anti-human Glycoprotein 1b alpha (GP1b alpha subunit) antibody&nbsp;ImmunogenPlatelet membranes&nbsp;RelevanceGlycoprotein 1b is heavily expressed in platelets and megakaryocytes. It serves as a receptor for von Willebrandt Factor and thrombin.&nbsp;Cross reactivityRecognises human GP1b, other species to be tested.&nbsp;SpecificityEpitope not mapped.&nbsp;Tested ApplicationsWestern blotting, flow cytometry immunohistochemistry, immunofluorescence.&nbsp;Raised inMouse&nbsp;ClonalityMonoclonal&nbsp;IsotypeIgG1&nbsp;ReferencesThorsen LI et al (1998) Br. J. Haematol. 68, 67-74]]></description><pubDate>Wed, 14 Apr 2010 08:45:21 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4916</guid></item><item><title>HIV-1 p17 Gag monoclonal antibody - Clone 17-2</title><caseId>501/0988</caseId><link>http://kingsbusiness.technologypublisher.com/technology/4912</link><description><![CDATA[Reagent NameHIV-1 p17 Gag monoclonal antibody (#17-2)&nbsp;DescriptionHybridoma expressing antibodies to human immunodeficiency virus type 1&nbsp;ImmunogenBacterially expressed, hexahistidine amino-terminal tagged HIV-1 p17 Gag protein (clade B, HXB-3 isolate)&nbsp;Relevancep17 is encoded by the HIV gag gene and is an important structural component of the HIV particle&nbsp;Cross reactivityNot tested&nbsp;SpecificityEpitope not mapped&nbsp;Tested applicationsWestern blots for clade B isolates of HIV&nbsp;Raised in Mouse&nbsp;ClonalityMonoclonal&nbsp;IsotypeIgG1, k&nbsp;ReferencesFouchier RA, Me...]]></description><pubDate>Wed, 14 Apr 2010 08:45:15 GMT</pubDate><author>kingsbusiness-info@kcl.ac.uk</author><guid>http://kingsbusiness.technologypublisher.com/technology/4912</guid></item></channel></rss>