HIV-1 Vif Monoclonal Antibody - Clone 564

Reagent Name

HIV-1 Vif monoclonal antibody (#564)

Description

Hybridoma expressing antibodies to human immunodeficiency virus type 1

Immunogen

Bacterially expressed, hexahistidine amino-terminal tagged HIV-1 Vif protein (clade B, HXB-3 isolate)

Relevance

HIV-1 expresses the viral infectivity factor (vif) which induces productive viral replication by inactivating the host cell anti-HIV factor APOBEC3G

Cross-reactivity

No cross-reactivity with non-HIV-1 Vif proteins has been observed

Specificity

Epitope not yet mapped

Tested applications

Immunoprecipitation assays (not useful for Western blotting)

Raised in

Mouse

Clonality

Monoclonal

Isotype

IgG_{2a, k}

References

1. Simon JH, Southerling TE, Peterson JC, Meyer BE, Malim MH. Complementation of vif-defective human immunodeficiency virus type 1 by primate, but not nonprimate, lentivirus vif genes. J Virol 69:4166-4172, 1995.