Reagent name
HIV-1 integrase (IN) monoclonal antibody (#IN-2)
Description
Hybridoma expressing antibodies to human immunodeficiency virus type 1
Immunogen
Bacterially expressed, hexahistidine amino-terminal tagged HIV-1 integrase protein (clade B, HXB-3 isolate)
Relevance
HIV-1 expresses the integrase (IN) protein as part of the polymerase gene. It is the viral enzyme that catalyses the insertion of viral DNA into the chromosomal DNA of an infected cells. Integrase is essential for viral growth and is a therapeutic target.
Cross-reactivity
No cross-reactivity with non-HIV-1 integrase proteins has been observed
Specificity
Epitope not yet mapped
Tested applications
Western blots; immunofluorescence assays; immunoprecipitation assays
Raised in
Mouse
Clonality
Monoclonal
Isotype
IgG1, k
References